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Novel ligands designed to activate mu opioid receptors and provide analgesic effects without opioid-related side effects, providing specific insight into the cellular impact of opioid receptor-based activation as related to pain medications. These ligands could be used as a tool to negate drug tolerance and dependence as well as other adverse side effects.
KU researchers have invented a high-pressure reactor equipped with an internal ultrasonic mixer that is useful for preparing nanomaterials and for conducting reactions with ozone and other reactive gases. The apparatus facilitates the use of supercritical carbon dioxide (CO2) as a solvent, allowing the advantages of the solvent properties of the supercritical fluid and the agitation achievable using ultrasonic energy.
This invention provides a method for synthesizing a novel hydrogel that can switch its wettability and absorption for polar liquids and maintain its non-polar liquid repellency while requiring minimal heat input. The invention enables a separation method has the potential to reduce energy costs for some industrial processes and has been employed to separate immiscible polar-non-polar liquid mixtures (water and oil) and a completely miscible liquid mixture (ethanol and heptane) at room temperature.
A novel computer vision-based approach for fatigue crack detection using a video stream was developed. The technology offers significant advantages over traditional inspection and fixed sensor-based methods and overcomes many of the limitations and concerns with static image and image processing based techniques.
Photo-mediated Ultrasound Therapy (PUT) is a non-pharmacological, highly targeted, non-invasive treatment which selectively disrupts the microvasculature (arteries or veins independently) without catheterization/injection or damage to the surrounding tissue.
A low-cost telemedicine tool featuring a virtual reality (VR) interface has been designed and developed to assist with the evaluation and diagnosis of neurodegenerative disease, thereby enabling greater access to care and earlier diagnosis for patients with neurological disorders; even for those in remote areas, or with limited transportation options.
This invention provides a composition and method for effectively and responsibly degrading polymers using an enzyme. It is most applicable in hydraulic fracturing (fracking) applications in the oil and gas industry. The system has the ability to break down a wide variety of fracking polymers without the use of toxic chemicals, and has the potential to degrade other organic molecules and pollutants associated with remediation processes.
This invention combines the strengths of two commonly used mouse strains (C57BL/6J and FVB/N) to obtain a preferable nuclear genome amenable to pronuclear injection for mouse transgenesis.
The invention relates to protecting against Salmonella-type pathogens and more particularly, compositions and methods for immunizing against infection by typhoidal and non-typhoidal Salmonella serovars.
The invention consists of compounds for the treatment of parasitic diseases such as Trypanosomiasis and Leishmaniasis. Compounds are first-in-class, and selectively targeted towards pathogenic cells with nanomolar potency.