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Summary:
The small molecules in this work represent a novel composition of matter that can be used as either Kappa Opioid Receptor (KOR) agonists or antagonists. Further some of the compounds have been shown to weak agonists making them ideal to explore for the use of addiction.
Subcategory(s): biochemicals, small-molecules
Inventor(s): Jeffrey Aube, Kevin J. Frankowski, Kevin Li, Thomas E. Prisinzano, Partha Ghosh, David Whipple


Summary:
The invention describes CD44-selective nanovector systems for cancer-targeted delivery of molecular therapeutics.
Subcategory(s): healthcare, stem-cells
Keyword(s): cancer, nano
Inventor(s): Liang Xu , Xiaojie Meng , Xinbao Hao


Summary:
Broad based label-free systems identify protein stabilizers at physiological or near physiological conditions that specifically inhibit Bacterial Toxin or Viral entry into cells.
Category(s): biotechnology
Inventor(s): Mark Fisher & Subhashchandra Naik


Summary:
This invention is a tubular electrospun scaffold of natural protein gelatin and synthetic polyglycolic acid (PGA) / poly-lactic-co-glycolic (PLGA) polymers in a bioreactor system connected to a flow circuit and seeded with cultured fibroblasts and endothelial cells.
Subcategory(s): cell-lines, healthcare


Summary:
Our researcher at KUMC has developed methods of prediction, diagnosis, and treatment of primary osteoarthritis.
Category(s): therapeutics
Subcategory(s): healthcare
Inventor(s): Wang


Summary:
The invention consists of new bi-functional protein inhibitors (“BPIs”) for treatment and diagnostics of autoimmune diseases such as MS and experimental autoimmune encephalomyelitis. The novel BPIs are capable of modulating the immune response towards a TH2 response.
Category(s): therapeutics
Subcategory(s): biologics
Keyword(s): immunology


Summary:
This invention relates to a class of devices, the Radar Energy Absorbing Low Draw Vortex Generator (RAD-LDVG), which produce vortices over external or internal aerodynamic and/or hydrodynamic surfaces.
Category(s): engineering
Subcategory(s): transportation
Keyword(s): aerospace, radar, uav
Inventor(s): Ronald Barrett


Summary:
This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices. This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.
Inventor(s): Susan Lunte, Craig Lunte, Ryan Johnson, Nhan To, Damon Osbourn


Summary:
This invention combines the strengths of two commonly used mouse strains (C57BL/6J and FVB/N) to obtain a preferable nuclear genome amenable to pronuclear injection for mouse transgenesis.
Category(s): research-tools
Subcategory(s): animal-models
Inventor(s): Jay Vivian, Melissa Larson, Danny Welch, Carolyn Vivian


Summary:
This invention presents a novel series of modified cephalosporins, which exclusively target non-replicating mycobacterium tuberculosis.
Category(s): therapeutics
Subcategory(s): healthcare
Keyword(s): infectious-disease
Inventor(s): Frank Schoenen Jr, Jeffrey Aube, Carl Nathan, Robert Smith, Ben Gold, Quyen Nguyen

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