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This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices.  This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.  

Regenerating and repairing individual organs and tissues for a single patient requires mass quantities of the patient’s own adult stem cells. Mass production of adult stem cells for therapeutic applications is highly limited due to the fact that adult stem cells have a limited shelf life when isolated from primary tissues of humans and animals. The act of removing adult stem cells from their original environment is traumatic and has the potential to induce changes or negative effects. Furthermore, the ability to grow adult stem cells in environments that mimic the original host tissue are limited. Adult stem cells lose “stemness” characteristics and the ability to divide and differentiate as adult stem cells are maintained and dissociated (passaged) from growth substrates, as is current practice.

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This invention describes the first selective inhibitor of heat shock protein 90 kDa beta (Hsp90β). The invented inhibitor selectively binds to the N-terminus of Hsp90β and may be developed for the treatment of cancers. The inhibitor was developed based on the sequence alignment of the N-terminal ATP-binding domains of Hsp90α and Hsp90β complexed with a non-selective Hsp90 inhibitor, which revealed Hsp90β-specific residues that were key to exploit the selectivity of the new inhibitor. 

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Structural modification of a non-selective aminocyclohexanol-based heat shock protein 90 KDa (Hsp90) inhibitor led to a highly selective inhibitor of glucose regulated protein 94 kDa (Grp94). The new Grp94-selective inhibitor can be used to develop an effective therapy for the treatment of metastatic cancer and/or primary open angle glaucoma (POAG).

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Small camera/collection device that collects samples all along the surface of the esophagus, increasing disease detection rate.  

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This novel process uses atomic layer deposition (ALD) to grow a tunnel barrier one atomic layer at a time. Placed between two electrically conducting materials, a tunnel barrier forms a tunnel junction. Electrons pass through the barrier by quantum tunneling. This process forms more uniform, thinner, and lower defect tunnel barriers. By improving the likelihood of quantum tunneling, this process creates higher performing tunnel junction devices. 

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Use of a genetic dereplication strategy eliminates major known SM biosynthetic pathways in Aspergillus nidulans, reducing the complexity of SM profiles and activating an abundance of silent SM gene clusters to enable identification of a new pool of fungal products for drug discovery.

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This invention is a molecular screen to predict which patients’ non-invasive breast tumors will eventually progress to invasive breast cancers.

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A handheld surgical device that will allow safe, complete and controlled removal of subretinal fluid during retinal detachment repair surgery.

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Selective heat shock protein 90 (Hsp90) and glucose regulated protein 94 (Grp94) inhibitors that can be used to develop an effective therapy for treating primary open angle glaucoma (POAG).

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