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A novel method for detecting and monitoring the reactive nitrogen species peroxynitrite in normal physiology and human pathology. The invention offers significant advantages over traditional methods for detecting and monitoring the cellular production of peroxynitrite by overcoming limitations of other sensors. This is important because current methods are less sensitive and less robust, especially for studies of living cells such as its involvement in immunology. This invention may yield better information about the effects of peroxynitrite in a variety of diseases including infectious disease, cancer, neurodegeneration, and others.

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This invention is a method for isolating tumor-specific T cell receptors (TCRs) in a format that allows for rapid discovery, amplification, and return to a patient for therapeutic use.

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This invention is a method for improving electron microscopy image quality of a sample by increasing the electrical conductivity of the sample.  The increased conductivity of the sample counteracts detrimental surface charging typically caused by electron microscopes.  The method also increases the stability of the sample for higher quality serial sectioning.

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A novel method for measuring olfactory dysfunction. The method offers significant advantages over the traditional method for measuring olfactory dysfunction such as UPSIT and overcomes many of the limitations and concerns with its affordable, accessible, and user-friendly method to measure olfactory dysfunction using essential oils in alterable concentrations.

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A system for improving the performance of existing air conditioning and refrigeration approaches has been developed.

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A novel computer vision-based approach for fatigue crack detection using a video stream was developed.  The technology offers significant advantages over traditional inspection and fixed sensor-based methods and overcomes many of the limitations and concerns with static image and image processing based techniques.

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A reaction chamber utilizing the unique combination of high-pressure with ultrasonic mixing. This high-pressure chamber allows the use of liquid carbon dioxide, a “green solvent”. The synergistic accompaniment of ultrasonic mixing expands current chemical manufacturing possibilities.

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Mesenchymal stem cells isolated from human umbilical cord (hMSCs) are modified for the treatment of Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease).

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The technology presents a novel structural modification of an existing first generation Grp94 selective inhibitor to generate a second generation Grp94-specific scaffold which has greater affinity and selectivity compared to existing inhibitors and prevents unfavorable binding of other Hsp90 isoforms.

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Unique chemical derivatives invented by University of Kansas (KU) researchers that could be used to detect inhibitors of cellular efflux transporters and other agents. 

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